Jorge Santiago is the retired former Sengoku middleweight champion and the winner of the first and only Strikeforce middleweight grand prix.
He most recently defended his title in a rematch against Kazuo Misaki. After having been dominated in the fight four rounds to one going into the fifth, Santiago destroyed Misaki in that fifth round forcing Misaki's corner to throw in the towel with twenty-nine seconds remaining until a decision that Misaki would most certainly have won.
Months afterwards, Santiago vacated the Sengoku belt and secured his release from the promotion, planning on returning to fighting in the U.S. He next signed with the UFC and fought Brian Stann. Stann knocked Santiago out in the second round.
Santiago next faced long-time contender Demian Maia, losing via dominant unanimous decision. After the fight, Santiago was cut from the UFC.
He next signed with the upstart Titan FC promotion, making his debut against Leonardo Pecanha. Santiago defeated Pecanha via first round technical knockout.
Santiago next faced Justin Guthrie in June 2012, defeating Guthrie via first round heelhook submission.
Santiago next stepped in towards the end of January 2013 to return to the UFC at welterweight replacing Justin Edwards against undefeated prospect Gunnar Nelson. Santiago lost a relatively close decision to the prospect Nelson and his UFC future was already again uncertain. Indeed, Santiago was soon cut from the UFC.
Santiago next returned to middleweight to make his WSOF debut against fellow UFC veteran Gerald Harris. The winner was suspected to next fight UFC veteran Jon Fitch. Harris defeated Santiago via decision.
Santiago retired shortly afterwards.
- Jorge Santiago vs. Takuya Wada
- Jorge Santiago vs. Chris Leben
- Jorge Santiago vs. Andre Semenov
- Jeremy Horn vs. Jorge Santiago - The fight was amazingly Jeremy Horn's one hundredth fight.
- Jorge Santiago vs. Sean Salmon - The fight was in the semifinals of the first and only Strikeforce middleweight tournament.
- Jorge Santiago vs. Trevor Prangley - The fight was the finals of the first and only Strikeforce middleweight tourney. Santiago had won earlier that night knocking out Sean Salmon quickly, and Trevor Prangley had won earlier winning a decision over Falaniko Vitale. The fight was two five-minute rounds.
- Jorge Santiago vs. Kazuhiro Nakamura - The fight was in the finals of the Sengoku 2008 middleweight grand prix.
- Mamed Khalidov vs. Jorge Santiago 1
- Jorge Santiago vs. Kazuo Misaki 2 - The fight was for the Sengoku middleweight title with Santiago defending.
- Brian Stann vs. Jorge Santiago - The fight was Jorge Santiago's return to the UFC.
- Demian Maia vs. Jorge Santiago